Variant position: 55 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 326 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SGPWSLSPSDSSPSGVTSRL PGRSTSLVEGRSCGWVPPPPG
Mouse GGLWNIN-SDSIPSGVTSRL TGRSTSLVEGRSCGWVPPPPG
Rat GGLWNINSSDSIPSGVTSRL TGRSTSLVEGRSCSWVPPPPG
Bovine SGPWSLSSSDSSLPEVAARL PGRSTSLVEGRSCGWVPPPPG
Sheep SGPWSLSSSDSSLPEAAARL PGRSTSLVEGRSCGWVPPPPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 326 mRNA decay activator protein ZFP36
1 – 174 Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)
1 – 100 Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation
60 – 60 Phosphoserine; by MAPKAPK2
66 – 66 Phosphoserine
60 – 60 S -> A. Inhibits PKM-induced ZFP36 degradation through a p38 MAPK signaling pathway.
No reference for the current variant in UniProtKB/Swiss-Prot.
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