UniProtKB/SwissProt variant VAR

Potassium channel subfamily K member 16
Gene: KCNK16
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Variant information Variant position:

301
Type of variant:

LB/B
Residue change:

From Proline (P) to Histidine (H) at position 301 (P301H, p.Pro301His).
Physico-chemical properties:

Change from medium size and hydrophobic (P) to medium size and polar (H)
BLOSUM score:

-2
Other resources:

Variant rs11756091 [ dbSNP | Ensembl ]

Sequence information Variant position:

301
Protein sequence length:

309
Location on the sequence:

RRPRRGSTAARGVQVTPQDF P ISKKGLGS
Residue conservation:

Human                         RRPRRGSTAARGVQVTPQDFPISKKGLGS

Mouse                         SEPR------------SQKIPISA-----

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 309	Potassium channel subfamily K member 16
Topological domain	259 – 309	Cytoplasmic
Alternative sequence	222 – 309	TDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS -> HPLNFITPSGLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHSPGLAFPLPDCNIPDQERFRPLHPGAWKFWPLPLPSSNSKWAPMWLGSSAQV. In isoform c.
Alternative sequence	269 – 309	LRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS -> RGLGVKDGAASDPSGLPRPQKIPISA. In isoform b.

Literature citations
Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
Han J.; Kang D.; Kim D.;
Am. J. Physiol. 285:C529-C538(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; C AND D); FUNCTION; TRANSPORTER ACTIVITY; ACTIVITY REGULATION; TISSUE SPECIFICITY; ALTERNATIVE SPLICING; VARIANT HIS-301; Submission
Mural R.J.; Istrail S.; Sutton G.; Florea L.; Halpern A.L.; Mobarry C.M.; Lippert R.; Walenz B.; Shatkay H.; Dew I.; Miller J.R.; Flanigan M.J.; Edwards N.J.; Bolanos R.; Fasulo D.; Halldorsson B.V.; Hannenhalli S.; Turner R.; Yooseph S.; Lu F.; Nusskern D.R.; Shue B.C.; Zheng X.H.; Zhong F.; Delcher A.L.; Huson D.H.; Kravitz S.A.; Mouchard L.; Reinert K.; Remington K.A.; Clark A.G.; Waterman M.S.; Eichler E.E.; Adams M.D.; Hunkapiller M.W.; Myers E.W.; Venter J.C.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT HIS-301;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q96T55: Variant p.Pro301His