Sequence information
Variant position: 217 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 397 The length of the canonical sequence.
Location on the sequence:
GYFNDEMAPIEVKTKKGKQT
M QVDEHARPQTTLEQLQKLPP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GYFNDEMAPIEVKTKKGKQTM QVDEHARPQTTLEQLQKLPP
Mouse GYFNEEMAPIEVKTKKGKQTM QVDEHARPQTTLEQLQKLPS
Rat GYFNEEMAPIEVKTKKGKQTM QVDEHARPQTTLEQLQNLPP
Bovine GYFDNEMAPVEVKTRKGKQTM QVDEHPRPQTTMEQLNKLPP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 397
3-ketoacyl-CoA thiolase, mitochondrial
Binding site
224 – 224
Coenzyme A
Binding site
227 – 227
Coenzyme A
Modified residue
209 – 209
N6-acetyllysine; alternate
Modified residue
209 – 209
N6-succinyllysine; alternate
Modified residue
211 – 211
N6-succinyllysine
Modified residue
212 – 212
N6-succinyllysine
Modified residue
214 – 214
N6-succinyllysine
Modified residue
234 – 234
N6-acetyllysine; alternate
Modified residue
234 – 234
N6-succinyllysine; alternate
Beta strand
215 – 217
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.