Variant position: 309 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 868 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SRYDEYVNVKDFSDKINRAL AAAKKDNDFIYHDRVPDLKDL
Mouse SRYDEYVNVKDFSDKINRAL TAAKKDNDFIYHDRVPDLKDL
Rat SRYDEYVNVKDFSDKINRAL AAAKKDNDFIYHDRVPDLKDL
Xenopus laevis SRYDEYVNVKDLADKINRAL TAAKKDNDFIYHDRVPDLKDL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 868 Programmed cell death 6-interacting protein
3 – 392 BRO1
176 – 868 Interaction with EIAV p9
176 – 503 Interaction with CHMP4A, CHMP4B and CHMP4C
272 – 868 Missing. In isoform 3.
317 – 317 F -> A. Diminishes rescue of PTAP-type L domain-deficient HIV-1 p6.
318 – 318 I -> A. Greatly diminishes rescue of PTAP-type L domain--deficient HIV-1 p6.
319 – 319 Y -> A. Greatly diminishes rescue of PTAP-type L domain-deficient HIV-1 p6.
319 – 319 Y -> F. No effect on rescue of PTAP-type L domain-deficient HIV-1 p6.
298 – 317
Molecular cloning of human ALG-2 interacting protein 1 (AIP1).
Li H.; Shioda T.; Isselbacher K.J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-309 AND LEU-730;
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