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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P42771: Variant p.Arg124Cys

Cyclin-dependent kinase inhibitor 2A
Gene: CDKN2A
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Variant information Variant position: help 124
Type of variant: help LB/B
Residue change: help From Arginine (R) to Cysteine (C) at position 124 (R124C, p.Arg124Cys).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (C)
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 124
Protein sequence length: help 156
Location on the sequence: help LDVRDAWGRLPVDLAEELGH R DVARYLRAAAGGTRGSNHAR
Residue conservation: help 
Human                         LDVRDAWGRLPVDLAEELGHRDVARYLR-------------AAAGGTRG--------SNHAR

Mouse                         LDVRDAWGRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSL

Rat                           LDVRDAWGRLPLDLALERGHHDVVRYLR----------YLL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 156 Cyclin-dependent kinase inhibitor 2A
Repeat 110 – 139 ANK 4
Modified residue 140 – 140 Phosphoserine
Alternative sequence 117 – 156 Missing. In isoform 3.
Helix 124 – 130



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.