Variant position: 242 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 292 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ARNGLLTNHYVCEVDGQNVI GLKDKKIMEILATAGNVVTLT
Mouse ARNGLLTNHYVCEVNGQNVI GLKDKKVTEILTTAGDVITLT
Rat ARNGLLTNHYVCEVNGQNVI GLKDKKIIEILTTAGNVITLT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 292 Syntenin-2
192 – 267 PDZ 2
244 – 244 K -> A. Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197.
No reference for the current variant in UniProtKB/Swiss-Prot.
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