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UniProtKB/Swiss-Prot Q9Y5A9: Variant p.Pro454Ser

YTH domain-containing family protein 2
Gene: YTHDF2
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Variant information Variant position: help 454
Type of variant: help LB/B
Residue change: help From Proline (P) to Serine (S) at position 454 (P454S, p.Pro454Ser).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 454
Protein sequence length: help 579
Location on the sequence: help STEHGNKRLDAAYRSMNGKG P VYLLFSVNGSGHFCGVAEMK
Residue conservation: help 
Human                         STEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMK

Mouse                         STEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMK

Bovine                        STEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMK

Zebrafish                     STEHGNKRLDAAYRSLANKGPLYLLFSVNGSGHFCGVAEMR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 579 YTH domain-containing family protein 2
Domain 410 – 544 YTH
Region 385 – 579 Interaction with m6A-containing mRNAs
Binding site 462 – 462
Mutagenesis 441 – 441 R -> A. Slightly decreased binding to RNAs.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.