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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q13796: Variant p.Asp942Glu

Protein Shroom2
Gene: SHROOM2
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Variant information Variant position: help 942 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Aspartate (D) to Glutamate (E) at position 942 (D942E, p.Asp942Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and acidic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 942 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1616 The length of the canonical sequence.
Location on the sequence: help SPSTDHYKQEASVELRRQAG D PGEPREELPSAVRAEEGQST The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         SPSTDHYKQEASVELRRQAGDPGEPREELPSA-VRAEEGQST

Mouse                         SPSTDHYSQEVPVEPNRQAEDSGDHKEAILCT-LQAEEGCS

Rat                           SPSTDHYSQEVPVEPNRQAEDSGGQKEALLCT-LQAEEGCS

Xenopus tropicalis            SPTTDFYAQAAAVESKQQSESVRRDTENSNSTHCRSSTGDS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 1616 Protein Shroom2
Region 881 – 1100 Disordered
Compositional bias 881 – 954 Basic and acidic residues
Modified residue 922 – 922 Phosphoserine
Modified residue 924 – 924 Phosphoserine
Modified residue 925 – 925 Phosphothreonine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.