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UniProtKB/Swiss-Prot P34972: Variant p.Gln63Arg

Cannabinoid receptor 2
Gene: CNR2
Variant information

Variant position:  63
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Glutamine (Q) to Arginine (R) at position 63 (Q63R, p.Gln63Arg).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (Q) to large size and basic (R)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  High incidence in Japanese depressed subjects.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  63
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  360
The length of the canonical sequence.

Location on the sequence:   LGLLSALENVAVLYLILSSH  Q LRRKPSYLFIGSLAGADFLA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 360 Cannabinoid receptor 2
Topological domain 60 – 71 Cytoplasmic
Helix 62 – 65


Literature citations

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS ARG-63 AND TYR-316;

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.
Onaivi E.S.; Ishiguro H.; Gong J.-P.; Patel S.; Meozzi P.A.; Myers L.; Perchuk A.; Mora Z.; Tagliaferro P.A.; Gardner E.; Brusco A.; Akinshola B.E.; Hope B.; Lujilde J.; Inada T.; Iwasaki S.; Macharia D.; Teasenfitz L.; Arinami T.; Uhl G.R.;
PLoS ONE 3:E1640-E1640(2008)
Cited for: VARIANTS ARG-63 AND TYR-316;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.