Sequence information
Variant position: 8 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
MEKKCTL
Y FLVLLPFFMILVTAELEESP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEKKCTLN FLVLL---PFFMIL---VTAELEE-S--P-
Mouse MDKKHILC FLVLL---PLNMAL---ISA
Rat MDKKCTLC FLFLL---LLNMAL---IAA
Pig MEKKYILY FLFLL---PFFMIL---VIA
Bovine MEKKFFLS FLFLL---PFFMIL---VIA
Xenopus laevis LSRSALFK YIIIF---LIMINTRGYVLA
Xenopus tropicalis LLRSALFK YIIIV---LIMLNLRGYVLA
Zebrafish MTASCWTI CLFLLGSVTEFIVLASPEVN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Signal peptide
1 – 22
Literature citations
A cDNA encoding the calcitonin gene-related peptide type 1 receptor.
Aiyar N.; Rand K.; Elshourbagy N.A.; Zeng Z.; Adamou J.E.; Bergsma D.J.; Li Y.;
J. Biol. Chem. 271:11325-11329(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ASN-8;
A human orphan calcitonin receptor-like structure.
Fluehmann B.; Muff R.; Hunziker W.; Fischer J.A.; Born W.;
Biochem. Biophys. Res. Commun. 206:341-347(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ASN-8;
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
Kopatz S.A.; Aronstam R.S.; Sharma S.V.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ASN-8;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.