Variant position: 7 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 88 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVPLCQ VEVLYFAKSAEITGVRSETIS
Mouse MVPRCQ IDVLYFAKSAEIAGVRSETIS
Caenorhabditis elegans ---MIS IKVLFFGEACQLVGKREEAID
Drosophila DGPVVN VHVLFFAKSRELANTPRSTVE
Slime mold --MSNQ FKILLFAKVKEVIGKDSIFID
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 88 Molybdopterin synthase sulfur carrier subunit
7 – 11
Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.
Leimkuehler S.; Freuer A.; Araujo J.A.; Rajagopalan K.V.; Mendel R.R.;
J. Biol. Chem. 278:26127-26134(2003)
Cited for: FUNCTION; SUBUNIT; THIOCARBOXYLATION AT GLY-88; CHARACTERIZATION OF VARIANT MOCODB PHE-7;
Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency.
Johnson J.L.; Coyne K.E.; Rajagopalan K.V.; Van Hove J.L.K.; Mackay M.; Pitt J.; Boneh A.;
Am. J. Med. Genet. 104:169-173(2001)
Cited for: VARIANT MOCODB PHE-7;
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