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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P38570: Variant p.Val1019Ala

Integrin alpha-E
Gene: ITGAE
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Variant information Variant position: help 1019
Type of variant: help LB/B
Residue change: help From Valine (V) to Alanine (A) at position 1019 (V1019A, p.Val1019Ala).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to small size and hydrophobic (A)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 1019
Protein sequence length: help 1179
Location on the sequence: help FGAEYQLQICVPTKLRGLQV V AVKKLTRTQASTVCTWSQER
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 19 – 1179 Integrin alpha-E
Chain 179 – 1177 Integrin alpha-E heavy chain
Topological domain 19 – 1124 Extracellular
Disulfide bond 1008 – 1033



Literature citations
Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.
Shaw S.K.; Cepek K.L.; Murphy E.A.; Russell G.J.; Brenner M.B.; Parker C.M.;
J. Biol. Chem. 269:6016-6025(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PROTEIN SEQUENCE OF 19-38 AND 179-188; VARIANTS VAL-477; GLN-482 AND ALA-1019; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS VAL-477; GLN-482 AND ALA-1019;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.