Variant position: 1620 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2016 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ILSIVGTVLSDIIQKYFFSP TLFRVIRLARIGRILRLIRGA
Mouse ILSIVGTVLSDIIQKYFFSP TLFRVIRLARIGRILRLIRGA
Rat ILSIVGTVLSDIIQKYFFSP TLFRVIRLARIGRILRLIRGA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2016 Sodium channel protein type 5 subunit alpha
1608 – 1620 Extracellular
1510 – 1807 IV
1610 – 1610 D -> A. Complete loss of channel inhibition by the spider Jingzhaotoxin-I.
1610 – 1610 D -> R. High decrease in affinity to the sea anemone toxin anthopleurin-B.
1614 – 1614 K -> A. 4.2-fold decrease of channel inhibition potency by the spider Jingzhaotoxin-I.
No reference for the current variant in UniProtKB/Swiss-Prot.
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