Variant position: 72 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RKGNLERECVEETCSYEEAF EALESSTATDVFWAKYTACET
Mouse RKGNLERECVEEQCSYEEAF EALESPQDTDVFWAKYTVCDS
Rat RKGNLERECVEEQCSYEEAF EALESPQDTDVFWAKYTVCDS
Pig RKGNLERECVEEQCSREEAY EALESPSETDAFWAKYTACES
Bovine RKGNLERECLEEPCSREEAF EALESLSATDAFWAKYTACES
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
44 – 622 Prothrombin
44 – 198 Activation peptide fragment 1
44 – 89 Gla
57 – 57 4-carboxyglutamate
59 – 59 4-carboxyglutamate
62 – 62 4-carboxyglutamate
63 – 63 4-carboxyglutamate
68 – 68 4-carboxyglutamate
69 – 69 4-carboxyglutamate
72 – 72 4-carboxyglutamate
75 – 75 4-carboxyglutamate
67 – 74
Prothrombin Shanghai: hypoprothrombinaemia caused by substitution of Gla29 by Gly.
Wang W.; Fu Q.; Zhou R.; Wu W.; Ding Q.; Hu Y.; Wang X.; Wang H.; Wang Z.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT FA2D GLY-72;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.