Variant position: 326 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1214 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PQNSPPSSPSISRLTSRSSQ ESQRQAPELLVSPASDDIPTV
Mouse -------------------- ---------------------
Rat PQNSPPSSPSLSRLTSRSSQ QTQPQAPEVLVSPDRDDIPRV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1214 Sodium bicarbonate cotransporter 3
1 – 608 Extracellular
289 – 346 Disordered
312 – 334 Polar residues
1 – 450 Missing. In isoform 5.
251 – 374 Missing. In isoform 2, isoform 3, isoform 4, isoform 6, isoform 9, isoform 11, isoform 13 and isoform 14.
Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family.
Pushkin A.; Abuladze N.; Lee I.; Newman D.; Hwang J.; Kurtz I.;
J. Biol. Chem. 274:16569-16575(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); FUNCTION; BIOPHYSICOCHEMICAL PROPERTIES; REGULATION; VARIANT LYS-326;
Cloning and identification of novel human NBCn1 splice variants.
Liu Y.; Chen L.-M.; Parker M.D.; Boron W.F.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9; 10; 11 AND 12); ALTERNATIVE SPLICING; VARIANT LYS-326;
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