Variant position: 180 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 743 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GVMVYGRYDQFLREVLKLPT AVFEGPSFGYTEQSARSCFSQ
Mouse GVMVYGRYDQFLREVLKLPT AVFEGPSFGYTEQSARSCFSQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 743 Dystrobrevin alpha
1 – 288 Interaction with MAGEE1
1 – 318 Missing. In isoform 6, isoform 8, isoform 10 and isoform 11.
Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane.
Sadoulet-Puccio H.M.; Khurana T.S.; Cohen J.B.; Kunkel L.M.;
Hum. Mol. Genet. 5:489-496(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 5; 6; 7 AND 8); VARIANT GLU-180;
The genomic organization of human dystrobrevin.
Sadoulet-Puccio H.M.; Feener C.A.; Schaid D.J.; Thibodeau S.N.; Michels V.V.; Kunkel L.M.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3 AND 7); VARIANT GLU-180;
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