Variant position: 583 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 747 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSPDFVFMLSSKAGGCGLNL IGANRLVMFDPDWNPANDEQA
Mouse SSPDFVFMLSSKAGGCGLNL IGANRLVMFDPDWNPANDEQA
Zebrafish SSPEFIFMLSSKAGGCGLNL IGANRLVMFDPDWNPANDEQA
Drosophila ESDSFLFMLSSKAGGCGLNL IGANRLFMFDPDWNPANDEQA
Baker's yeast EGQEFIFLLSSKAGGCGINL IGANRLILMDPDWNPAADQQA
Fission yeast EKDAFVFLLSSKAGGCGINL IGANRLILFDPDWNPAADQQA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 747 DNA repair and recombination protein RAD54-like
500 – 653 Helicase C-terminal
572 – 572 Phosphoserine; by NEK1
572 – 572 S -> A. Defect in homologous recombination (HR).
572 – 572 S -> E. Promotes homologous recombination (HR), but causes RAD51 removal from chromatin.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLY-21; MET-74; CYS-202; GLN-380; CYS-534 AND THR-583;
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