Sequence information
Variant position: 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 345 The length of the canonical sequence.
Location on the sequence:
LYAGNDKWSIDPRVIILVNT
P TQYSIMIQNVDVYDEGPYTC
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LYAGNDKWSIDPRVIILVNTP TQYSIMIQNVDVYDEGPYTC
Chimpanzee LYAGNDKWSIDPRVIILVNTP TQYSIMIQNVDVYDEGPYTC
Rat LYAGNDKWSIDPRVIILVNTP TQYSIMIQNVDVYDEGPYTC
Bovine LYAGNDKWSIDPRVIILVNTP TQYSIMIQNVDVYDEGPYTC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
28 – 322
Opioid-binding protein/cell adhesion molecule
Domain
39 – 126
Ig-like C2-type 1
Disulfide bond
57 – 115
Literature citations
OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.
Sellar G.C.; Watt K.P.; Rabiasz G.J.; Stronach E.A.; Li L.; Miller E.P.; Massie C.E.; Miller J.; Contreras-Moreira B.; Scott D.; Brown I.; Williams A.R.; Bates P.A.; Smyth J.F.; Gabra H.;
Nat. Genet. 34:337-343(2003)
Cited for: VARIANT OVARIAN CANCER ARG-95;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.