Variant position: 162 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 935 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DCFIPCTPKGCLELIKETGV PIAGRHAVVVGRSKIVGAPMH
Mouse DCFIPCTPKGCLELIKEAGV QIAGRHAVVVGRSKIVGAPMH
Rat DCFIPCTPKGCLELIKETGV QIAGRHAVVVGRSKIVGAPMH
Drosophila G-FLPCTPWGCLELIRRSGV EIAGARAVVLGRSKIVGTPAA
Baker's yeast PFFLPCTPKGIIELLHKANV TIEGSRSVVIGRSDIVGSPVA
Fission yeast PLFTACTPKGIMCILKHYGI NVQGKHAVVIGRSNIVGRPMS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 935 C-1-tetrahydrofolate synthase, cytoplasmic
2 – 935 C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
2 – 291 Methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase (D/C) domain
147 – 147 C -> Q. Reduced methylenetetrahydrofolate dehydrogenase (NADP+) activity by 50%. Reduced methenyltetrahydrofolate cyclohydrolase activity by 87%.
No reference for the current variant in UniProtKB/Swiss-Prot.
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