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UniProtKB/Swiss-Prot P05177: Variant p.Arg457Trp

Cytochrome P450 1A2
Gene: CYP1A2
Variant information

Variant position:  457
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Tryptophan (W) at position 457 (R457W, p.Arg457Trp).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to large size and aromatic (W)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism:  The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).
Additional information on the polymorphism described.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  457
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  516
The length of the canonical sequence.

Location on the sequence:   GTAINKPLSEKMMLFGMGKR  R CIGEVLAKWEIFLFLAILLQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ

                              GTTINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQ

Mouse                         NSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQ

Rat                           NTAIDKTLSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLH

Rabbit                        GAAINKPLSEKVTLFGLGKRRCIGETLARWEVFLFLAILLQ

Cat                           GTAINKILSEKVMIFGLGKRRCIGEVLAKWEVFLFLAILLQ

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 516 Cytochrome P450 1A2
Metal binding 458 – 458 Iron (heme axial ligand)


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.