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UniProtKB/Swiss-Prot P29317: Variant p.Met631Thr

Ephrin type-A receptor 2
Gene: EPHA2
Variant information

Variant position:  631
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Methionine (M) to Threonine (T) at position 631 (M631T, p.Met631Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and hydrophobic (M) to medium size and polar (T)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  631
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  976
The length of the canonical sequence.

Location on the sequence:   SCVTRQKVIGAGEFGEVYKG  M LKTSSGKKEVPVAIKTLKAG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAG

Mouse                         SCVARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAG

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 24 – 976 Ephrin type-A receptor 2
Topological domain 559 – 976 Cytoplasmic
Domain 613 – 875 Protein kinase
Region 606 – 906 Mediates interaction with ARHGEF16 and ELMO2
Binding site 646 – 646 ATP
Modified residue 628 – 628 Phosphotyrosine
Modified residue 647 – 647 Phosphothreonine
Alternative sequence 498 – 976 Missing. In isoform 2.
Mutagenesis 646 – 646 K -> M. Loss of kinase activity.
Beta strand 625 – 632


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.