Variant position: 112 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 207 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ESFTRQVLWKLLKVVKFGEV ISYQQLAALAGNPKAARAVGG
Mouse DSFTRQVLWKLLKVVKFGET VSYQQLAALAGNPKAARAVGG
Rat DSFTRQVLWKLLKVVKFGEM VSYQQLAALAGNPKAARAVGG
Baker's yeast K------VWNELLNVEHGHV VTYGDIAKRIGKPTAARSVGR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 207 Methylated-DNA--protein-cysteine methyltransferase
95 – 95 DNA; via amide nitrogen
114 – 114 DNA
115 – 115 DNA; via amide nitrogen
123 – 123 DNA
128 – 128 DNA
114 – 114 Y -> A. Decreases activity towards methylated DNA over 1000-fold. Slightly reduced reactivity with O6-benzylguanine.
114 – 114 Y -> E. Loss of DNA repair activity. Slightly reduced reactivity with O6-benzylguanine.
128 – 128 R -> AD. Decreases activity towards methylated DNA over 1000-fold. No effect on reactivity with O6-benzylguanine.
128 – 128 R -> G. Loss of DNA repair activity.
128 – 128 R -> KL. Slightly reduced DNA repair activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.