Variant position: 69 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1129 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGPGGPGGGGAGGPGGAGAG AAAGQLDAQVGPEGILQNGAV
Mouse GGP-----GGAGGPGGAGAG GAAGQLDAQVGPEGILQNGAV
Caenorhabditis elegans D------------------- --------------LLPGGTD
Drosophila Q------------------- ------NDQLEIAQRCSAGDS
Slime mold ENQQQQNNNNNNNKNQFEDD DEDQEEEEYISGDDLNNNGQE
Fission yeast -------------------- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1129 Regulator of nonsense transcripts 1
1 – 415 Sufficient for interaction with RENT2
47 – 80 Ala/Gly/Pro-rich
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
Nagase T.; Seki N.; Ishikawa K.; Ohira M.; Kawarabayasi Y.; Ohara O.; Tanaka A.; Kotani H.; Miyajima N.; Nomura N.;
DNA Res. 3:321-329(1996)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT SER-69;
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