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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8NF91: Variant p.Lys3874Thr

Nesprin-1
Gene: SYNE1
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Variant information Variant position: help 3874
Type of variant: help LB/B
Residue change: help From Lysine (K) to Threonine (T) at position 3874 (K3874T, p.Lys3874Thr).
Physico-chemical properties: help Change from large size and basic (K) to medium size and polar (T)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 3874
Protein sequence length: help 8797
Location on the sequence: help AQLSKYKSLQQTVLSHEPSV K SVREKGEALLELVQDVTLKD
Residue conservation: help
Human                         AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKD

Mouse                         AQLSKYKSLQQMVLSHEPSVTSVQEKSEALLELVQDQSLKD

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 8797 Nesprin-1
Topological domain 1 – 8746 Cytoplasmic
Repeat 3815 – 3920 Spectrin 34
Coiled coil 314 – 8666
Alternative sequence 1 – 7843 Missing. In isoform 9.
Alternative sequence 1 – 7838 Missing. In isoform 3.
Alternative sequence 1 – 7658 Missing. In isoform 11.
Alternative sequence 1 – 5585 Missing. In isoform 8.
Alternative sequence 1 – 5476 Missing. In isoform 2.
Alternative sequence 1444 – 8797 Missing. In isoform 5.
Alternative sequence 1726 – 8797 Missing. In isoform 6.
Alternative sequence 3050 – 8797 Missing. In isoform 10.
Alternative sequence 3395 – 8797 Missing. In isoform GSRP-56.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.