Variant position: 96 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 337 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAECTAMGLRSGNLRDRFWL VINQEGNMVTARQEPRLVLIS
Mouse EAECTAMGLRYGHLRDRFWL VINEEGNMVTARQEPRLVLIS
Xenopus laevis EAECSALGLKSGHLEDRHWL VVTEEGNMVTARQEPRMVLIS
Zebrafish AAECLRMGLKYGELRDRHWL VITEDGHMVTGRQQPRLVLVS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 337 Mitochondrial amidoxime-reducing component 1
41 – 337 Cytoplasmic
93 – 183 MOSC N-terminal region
92 – 92
1 – 102 Missing. In isoform 3.
94 – 97
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-15; LEU-96; ALA-165; SER-246 AND HIS-247;
Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians.
Ott G.; Reichmann D.; Boerger C.; Cascorbi I.; Bittner F.; Mendel R.R.; Kunze T.; Clement B.; Havemeyer A.;
Drug Metab. Dispos. 42:718-725(2014)
Cited for: VARIANTS ALA-165; LYS-187; SER-246 AND HIS-247; CHARACTERIZATION OF VARIANTS LEU-96; ALA-165; LYS-187; SER-246; HIS-247 AND ILE-268; BIOPHYSICOCHEMICAL PROPERTIES; COFACTOR;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.