Variant position: 1575 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2426 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TSPVGEIGEEKILPTSETKQ RTVLDTYPGVSEADAGETLSS
Mouse VGPVGEASEEKILPISETKE ITELATCAAVSEADIGRSLSS
Drosophila -------------------- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 2426 Protein SON
1556 – 1556 Phosphoserine
690 – 2416 Missing. In isoform H.
Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON.
Sun C.-T.; Lo W.-Y.; Wang I.-H.; Lo Y.-H.; Shiou S.-R.; Lai C.-K.; Ting L.-P.;
J. Biol. Chem. 276:24059-24067(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM G); VARIANTS SER-473 AND LEU-1202; CYS-1575;
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Kikuno R.; Nagase T.; Ishikawa K.; Hirosawa M.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 6:197-205(1999)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B); VARIANTS SER-473 AND LEU-1202; CYS-1575;
Human partial CDS from CD34+ stem cells.
Ye M.; Zhang Q.-H.; Zhou J.; Shen Y.; Wu X.-Y.; Guan Z.Q.; Wang L.; Fan H.-Y.; Mao Y.-F.; Dai M.; Huang Q.-H.; Chen S.-J.; Chen Z.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114; VARIANT CYS-1575;
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