Sequence information
Variant position: 134 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 223 The length of the canonical sequence.
Location on the sequence:
EAHKEAMSRKLGQSESQGPP
R AFAKVNSISPGSPASIAGLQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAHKEAMSRKLGQSES-----------QGPPR --------AFAKVNSISPGSPASIAGLQ
Mouse EAREEAMNRRLASNS------------PVLPQ --------A
Rat EAREEAMNRRLASDS------------PALPK --------A
Bovine EAHREALSRDQSQG-------------LSPAQ --------A
Caenorhabditis elegans ---SEEKPVHRTSNE----------------- --------P
Drosophila SALDLDSDRSPGGANITD---------LAPAR --------A
Slime mold STSNNNNNNNEDEMKIDKPLTVETETKPKPIE VEVEKVGIP
Baker's yeast ---DARRNNDDQAIQYTI-------------- --------P
Fission yeast KLAQEADPLNFNAANYNMNDIISRSKILGRVK --------P
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 223
26S proteasome non-ATPase regulatory subunit 9
Domain
108 – 195
PDZ
Region
103 – 141
Disordered
Compositional bias
124 – 141
Polar residues
Modified residue
129 – 129
Phosphoserine
Alternative sequence
47 – 151
Missing. In isoform 3.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.