Variant position: 351 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 668 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NGEELTLSNCSWRFNNSNLC SQSLAARVLCSASRSLHNLST
Mouse KGQEPALSTCSWRFNNSNLC SQSRAARVVCSGSQRHLNLST
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 668 T-cell differentiation antigen CD6
18 – 402 Extracellular
265 – 361 SRCR 3
339 – 339 N-linked (GlcNAc...) asparagine
345 – 345 N-linked (GlcNAc...) asparagine
368 – 368 N-linked (GlcNAc...) asparagine
303 – 360
259 – 359 Missing. In isoform 7.
261 – 383 Missing. In isoform 6.
346 – 346 N -> A. Strongly reduces interaction with ALCAM.
349 – 349 L -> A. Reduces interaction with ALCAM.
352 – 352 Q -> A. Reduces interaction with ALCAM.
353 – 353 S -> A. Reduces interaction with ALCAM.
350 – 352
Structures of CD6 and its ligand CD166 give insight into their interaction.
Chappell P.E.; Garner L.I.; Yan J.; Metcalfe C.; Hatherley D.; Johnson S.; Robinson C.V.; Lea S.M.; Brown M.H.;
Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 1-364; DISULFIDE BONDS; GLYCOSYLATION AT ASN-28 ASN-49 AND ASN-229; IDENTIFICATION BY MASS SPECTROMETRY; INTERACTION WITH ALCAM; CHARACTERIZATION OF VARIANT ASN-351; MUTAGENESIS OF ASP-291; GLU-293; TYR-295; GLU-298; ARG-314; TYR-327; SER-329; ASN-346; LEU-349; GLN-352 AND SER-353;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.