Variant position: 1530 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1942 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QQQARFQQWSEHHAFLSQGS APYPHHHHPHLQHLPQPPLGL
Mouse QQQARLQQWSEHHAYLSQGG IPYSHHHHPHLPHLPHTPIGL
Zebrafish QQQARVGQWGEHTPFLPAGV APFPLPQQ--LAHLAQP--GL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1942 Probable helicase with zinc finger domain
1527 – 1552 Disordered
1163 – 1942 Missing. In isoform 2.
No reference for the current variant in UniProtKB/Swiss-Prot.
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