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UniProtKB/Swiss-Prot Q66GS9: Variant p.Ile769Leu

Centrosomal protein of 135 kDa
Gene: CEP135
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Variant information Variant position: help 769
Type of variant: help LB/B
Residue change: help From Isoleucine (I) to Leucine (L) at position 769 (I769L, p.Ile769Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 769
Protein sequence length: help 1140
Location on the sequence: help KIANLQENLANKEKAVAQMK I MISECESSVNQLKETLVNRD
Residue conservation: help 
Human                         KIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRD

Mouse                         KIANLQESLLSKEKVIAQLKVTVAEYETSLNQLQETLTTRD

Zebrafish                     SVVLLQQEVHRKEETLLEVRLTVTDLENSLNQLQAVLSSRE

Drosophila                    KLVKLDRVLHETMRLIPAVPLLIRQTSHSI-QLSNGFYIPE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1140 Centrosomal protein of 135 kDa
Coiled coil 668 – 1036
Alternative sequence 250 – 1140 Missing. In isoform 2.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.