Sequence information
Variant position: 769 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1262 The length of the canonical sequence.
Location on the sequence:
EDCVMALETLFSVLLSLCRL
M APYTPFLTELMYQNLKVLID
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EDCVMALETLFSVLLSLCRLM APYTPFLTELMYQNLKVLID
Mouse EDCVMALETLFSVLLSLCRLM APYTPFLTELMYQNLKLLID
Caenorhabditis elegans HEQHHALAALGRVLILIVRLM APFTPFFCEYIWLNLKKVI-
Slime mold ADCLAALNILYEVLMTICIAM GPFTPFFTEYMYQNLKKALP
Baker's yeast EDCLKALNSLFDALFTFVRAM APFTPFLSESIYLRLKEYIP
Fission yeast IETINALNVLFEVLFTLVRIM GPFTPFITENIYQHLRNYMP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1262
Isoleucine--tRNA ligase, cytoplasmic
Literature citations
Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension.
Nichols R.C.; Raben N.; Boerkoel C.F.; Plotz P.H.;
Gene 155:299-304(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PARTIAL PROTEIN SEQUENCE; SUBCELLULAR LOCATION; VARIANT ILE-769;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.