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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P02730: Variant p.Thr837Arg

Band 3 anion transport protein
Gene: SLC4A1
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Variant information Variant position: help 837
Type of variant: help LP/P [Disclaimer]
Residue change: help From Threonine (T) to Arginine (R) at position 837 (T837R, p.Thr837Arg).
Physico-chemical properties: help Change from medium size and polar (T) to large size and basic (R)
BLOSUM score: help -1
Variant description: help In SPH4; Nagoya.


Sequence information Variant position: help 837
Protein sequence length: help 911
Location on the sequence: help KYHPDVPYVKRVKTWRMHLF T GIQIICLAVLWVVKSTPASL
Residue conservation: help 
Human                         KYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASL

Mouse                         KYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASL

Rat                           KYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASL

Chicken                       KYHPKEPYVTRVKTWRITSSPLTQILVVALLWGVKVSPASL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 911 Band 3 anion transport protein
Topological domain 801 – 838 Cytoplasmic
Lipidation 843 – 843 S-palmitoyl cysteine
Helix 830 – 851



Literature citations
Characteristic features of the genotype and phenotype of hereditary spherocytosis in the Japanese population.
Yawata Y.; Kanzaki A.; Yawata A.; Doerfler W.; Oezcan R.; Eber S.W.;
Int. J. Hematol. 71:118-135(2000)
Cited for: VARIANTS SPH4 ARG-130; ARG-455; ARG-714; TRP-760; GLN-760; HIS-808; ARG-837 AND MET-837; VARIANTS ALA-38; GLU-56; ASP-72 AND LEU-854;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.