Variant position: 860 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 980 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QD--VFVIGATNRPDLLDPALL RPGRFDKLVFVGANEDRASQL
Mouse QD--VFVIGATNRPDLLDPALL RPGRFDKLVFVGASEDRAS
Rat QD--VFVIGATNRPDLLDPALL RPGRFDKLVFVGASEDRAS
Slime mold SD--VFIIGATNRPDLLDSSLM RPGRLDRLLYLGISSEKEN
Baker's yeast ADG-VFVIGATNRPDLLDEALL RPGRFDKLLYLGIPDTDTK
Fission yeast NNKYVFVIGATNRPDLLDPSLL RPGRFDKLVYLGINKSEES
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 980 Peroxisome assembly factor 2
739 – 980 Missing. In isoform 2.
Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.
Yik W.Y.; Steinberg S.J.; Moser A.B.; Moser H.W.; Hacia J.G.;
Hum. Mutat. 30:E467-E480(2009)
Cited for: INVOLVEMENT IN PBD-CG4; INVOLVEMENT IN HMLR2; VARIANTS PBD-CG4 THR-849; GLN-860 AND TRP-860; VARIANTS HMLR2 LEU-274 AND GLN-601; VARIANTS PRO-79; VAL-809; ILE-882; SER-924 AND GLN-939;
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