Sequence information
Variant position: 209 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 320 The length of the canonical sequence.
Location on the sequence:
WKNVPKTQMKFSIQTMCPIE
G EGNIARFLFSLFGQKHNAVN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WKNVPKTQMKFSIQTMCPIEG EGNIARFLFSLFGQKHNAVN
Mouse WKNVPKTQMKFSVQTMCPIEG EGNIARFLFSLFGQKHNAVT
Rat WKNVPKTQMKFSVQTMCPIEG EGNIARFLFSLFGQKHNAVH
Bovine WKDVPKTQMKFSVQTMCPIEG EGNIARFLFSLFGQKQDAVN
Drosophila WKNCEHTEMISSPTMYVPIYG EVNIIRYLGRVGPAEYRYEG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 320
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Region
162 – 225
Interaction with TP53
Mutagenesis
215 – 215
R -> A. Nearly abolishes interaction with EPRS1.
Beta strand
207 – 209
Literature citations
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
Han J.M.; Park B.-J.; Park S.G.; Oh Y.S.; Choi S.J.; Lee S.W.; Hwang S.-K.; Chang S.-H.; Cho M.-H.; Kim S.;
Proc. Natl. Acad. Sci. U.S.A. 105:11206-11211(2008)
Cited for: INTERACTION WITH TP53; VARIANTS VAL-92; 97-ASP--SER-99 AND SER-209; MUTAGENESIS OF 163-GLU-ASN-164 AND 172-GLN-ASN-173;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.