Variant position: 361 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 725 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KLLQSAK-------TILRGTEEKCGSP QVRTLSG-SRPPLLRPLSENSG
Mouse RLLQSAK-------TILRGTEEKCGSP RIRTLSS-SRPPLL
Rat KLLQSAK-------TILRGTEEKCGSP RIRTLSG-SRPPLL
Caenorhabditis elegans EVAAKQKKSCIVPPTVFEARRNRISSE CVHVEHGISMDQLR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 725 Eukaryotic elongation factor 2 kinase
348 – 348 Phosphothreonine; by autocatalysis
353 – 353 Phosphothreonine; by autocatalysis
359 – 359 Phosphoserine; by MAPK13 and CDK1
366 – 366 Phosphoserine; by autocatalysis, RPS6KA1 and RPS6KB1
348 – 348 T -> A. Decreased kinase activity.
366 – 366 S -> A. Abrogates phosphorylation by RPS6KB1.
366 – 366 S -> A. Decreased kinase activity.
Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.
Ryazanov A.G.; Ward M.D.; Mendola C.E.; Pavur K.S.; Dorovkov M.V.; Wiedmann M.; Erdjument-Bromage H.; Tempst P.; Parmer T.G.; Prostko C.R.; Germino F.J.; Hait W.N.;
Proc. Natl. Acad. Sci. U.S.A. 94:4884-4889(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; CATALYTIC ACTIVITY; VARIANT ARG-361;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS ARG-23 AND ARG-361;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.