Variant position: 122 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 557 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SFDVISDDAFIGLPHLEYLF IENNNIKSISRHTFRGLKSLI
Chimpanzee SFDVISDDAFIGLPHLEYLF IENNNIKSISRHTFRGLKSLI
Mouse SFDVISDDAFIGLPHLEYLF IENNNIKSISRHTFRGLKSLI
Rat SFDVISDDAFIGLPHLEYLF IENNNIKSISRHTFRGLKSLI
Bovine SFDVISDDAFIGLPHLEYLF IENNNIKSISRHTFRGLKSLI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
35 – 557 Leucine-rich glioma-inactivated protein 1
116 – 137 LRR 2
96 – 143 Missing. In isoform 3.
119 – 124
A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy.
Striano P.; de Falco A.; Diani E.; Bovo G.; Furlan S.; Vitiello L.; Pinardi F.; Striano S.; Michelucci R.; de Falco F.A.; Nobile C.;
Arch. Neurol. 65:939-942(2008)
Cited for: VARIANT ETL1 LYS-122;
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