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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P20036: Variant p.Ala42Met

HLA class II histocompatibility antigen, DP alpha 1 chain
Gene: HLA-DPA1
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Variant information Variant position: help 42
Type of variant: help LB/B
Residue change: help From Alanine (A) to Methionine (M) at position 42 (A42M, p.Ala42Met).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (M)
BLOSUM score: help -1
Polymorphism: help The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.
Variant description: help In allele DPA1*02:02, allele DPA1*02:04, allele DPA1*03:01, allele DPA1*03:02 and allele DPA1*03:03; requires 2 nucleotide substitutions.
Other resources: help


Sequence information Variant position: help 42
Protein sequence length: help 260
Location on the sequence: help FLLSLRGAGAIKADHVSTYA A FVQTHRPTGEFMFEFDEDEM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 29 – 260 HLA class II histocompatibility antigen, DP alpha 1 chain
Topological domain 29 – 222 Extracellular
Region 29 – 115 Alpha-1
Beta strand 35 – 49



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.