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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P02724: Variant p.Glu24Asp

Glycophorin-A
Gene: GYPA
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Variant information Variant position: help 24 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glutamate (E) to Aspartate (D) at position 24 (E24D, p.Glu24Asp). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and acidic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help Along with GYPB, GYPA is responsible for the MNS blood group system [MIM:111300]. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M; 'Leu-20' and 'Glu-24' correspond to N (shown).GYPA polymorphisms are involved in resistance to malaria [MIM:611162]. - Additional information on the polymorphism described.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 24 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 150 The length of the canonical sequence.
Location on the sequence: help KIIFVLLLSEIVSISALSTT E VAMHTSTSSSVTKSYISSQT The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         KIIFVLLLSEIVSIS-------------ASSTTGVAMHTSTSSSVTKSYISSQT

                              KIVIVLLLSGYISTQ---------------------DVTEI

Chimpanzee                    KIIFVLLLSAIVSIS-------------ASSTTEVAMHT-S

Mouse                         STAAVTTSGHSLTTTFHIPSSQHYQEEHSPSLSGSDSLLQI

Pig                           ----------------------------------------T

Horse                         ---------QTIATG-------------SPPIAGTSDLSTI

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 20 – 150 Glycophorin-A
Topological domain 20 – 91 Extracellular
Glycosylation 21 – 21 O-linked (GalNAc...) serine
Glycosylation 22 – 22 O-linked (GalNAc...) threonine
Glycosylation 23 – 23 O-linked (GalNAc...) threonine
Glycosylation 29 – 29 O-linked (GalNAc...) threonine
Glycosylation 30 – 30 O-linked (GalNAc...) serine
Glycosylation 31 – 31 O-linked (GalNAc...) threonine
Glycosylation 32 – 32 O-linked (GalNAc...) serine
Glycosylation 36 – 36 O-linked (GalNAc...) threonine
Glycosylation 38 – 38 O-linked (GalNAc...) serine
Glycosylation 41 – 41 O-linked (GalNAc...) serine
Glycosylation 44 – 44 O-linked (GalNAc...) threonine
Alternative sequence 1 – 26 Missing. In isoform 2.
Alternative sequence 13 – 45 Missing. In isoform 3.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.