Variant position: 84 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 150 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EISVRTVYPPEEET-GERVQL AHHFSEPEITLIIFGVMAGVI
Chimpanzee EIYVTTVYPPEEEN-GEGVQL VHRFSEPEITLIIFGVMAGV
Mouse VSAAFEEQPVSPHIGGMPSPI QHDFPALVMILIILGVMAGI
Pig VMTIKNTTAVVQKETGVPESY HQDFSHAEITGIIFAVMAGL
Horse ----------DGREQGDGLQL AHDFSQPVITVIILGVMAGI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 150 Glycophorin-A
20 – 91 Extracellular
66 – 66 O-linked (GalNAc...) serine
69 – 69 O-linked (GalNAc...) threonine
87 – 87 F -> C. Diminishes dimerization.
88 – 88 S -> C. Diminishes dimerization.
90 – 90 P -> C. Diminishes dimerization.
91 – 91 E -> C. Diminishes dimerization.
94 – 94 L -> I. Diminishes dimerization.
95 – 95 I -> A. Diminishes dimerization.
98 – 98 G -> L. Diminishes dimerization.
102 – 102 G -> L. Abolishes dimerization.
84 – 86
Glycophorin A mutation Ala65 --> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wrb expression: direct evidence for GPA/band 3 interaction necessary for normal Wrb expression.
Poole J.; Banks J.; Bruce L.J.; Ring S.M.; Levene C.; Stern H.; Overbeeke M.A.; Tanner M.J.;
Transfus. Med. 9:167-174(1999)
Cited for: VARIANT ENEP/HAG PRO-84;
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