Variant position: 1056 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2382 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LESTQGVSQVAPAEPVAVAQ TQATQPTTLASSVD-SAHSDVA
Mouse LESTQGVSQAAPPEQTPITQ SQPTQPVPLVTSAD-SAHSDV
Rat -SSTQGVSQAAPPEQTPITQ SQPTQPVPLVSSVD-SAHSDV
Pig LESTQGVSQVAPPEPVPAAP PQPTQPTTLVSSIDRSAHSDV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2382 Serine/threonine-protein kinase WNK1
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
Verissimo F.; Jordan P.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; CHROMOSOMAL LOCATION; VARIANTS PRO-1056; SER-1506 AND ILE-1808;
NHLBI resequencing and genotyping service (RS&G);
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS PRO-1056; SER-1506 AND ILE-1808;
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T.; Ishikawa K.; Nakajima D.; Ohira M.; Seki N.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 4:141-150(1997)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-2382 (ISOFORM 2); VARIANTS PRO-1056 AND SER-1506;
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