Variant position: 98 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 358 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SEYWDRETRSARDTAQIFRV NLRTLRGYYNQSEAGSHTLQW
Chimpanzee SEYWDRETRSARDTAQIFRV NLRTLRGYYNQSEAGSHTLQW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 358 HLA class I histocompatibility antigen, alpha chain E
22 – 305 Extracellular
22 – 111 Alpha-1
98 – 98 Peptide antigen; self-peptide antigen
105 – 105 Peptide antigen; self-peptide antigen
107 – 107 N-linked (GlcNAc...) asparagine
83 – 83 R -> A. Has no impact on the affinity for KLRD1-KLRC1.
86 – 86 R -> A. Reduces the affinity for KLRD1-KLRC1.
90 – 90 D -> A. Has no impact on the affinity for KLRD1-KLRC1.
93 – 93 Q -> A. Impairs the recognition by KLRD1-KLRC1.
96 – 96 R -> A. Abolishes the recognition by KLRD1-KLRC1.
97 – 97 V -> A. Impairs the recognition by KLRD1-KLRC1.
100 – 100 R -> A. Reduces the affinity for KLRD1-KLRC1.
110 – 110 E -> A. Has no impact on the affinity for KLRD1-KLRC1.
78 – 105
No reference for the current variant in UniProtKB/Swiss-Prot.
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