Variant position: 736 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 886 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EEEEE-ISMAQIPCTAQEALT AQGLSGVEEALDATIAWEASP
Mouse EDEEDSLEVPGLPCTEETLLA P------HDTRAQAMEQSKV
Rat EEEEDSLEVPGLPTTEETFLA A------EDARAQAVDWSKV
Drosophila SDQENLAEL------------ --------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 886 cAMP-specific 3',5'-cyclic phosphodiesterase 4A
658 – 886 Missing. In isoform 5.
Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19.
Horton Y.M.; Sullivan M.; Houslay M.D.;
Biochem. J. 308:683-691(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5); VARIANT GLU-736;
Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.
Livi G.P.; Kmetz P.; McHale M.M.; Cieslinski L.B.; Sathe G.M.; Taylor D.P.; Davis R.L.; Torphy T.J.; Balcarek J.M.;
Mol. Cell. Biol. 10:2678-2686(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-886; VARIANT GLU-736;
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