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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9H867: Variant p.Ala63Asp

Protein N-lysine methyltransferase METTL21D
Gene: VCPKMT
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Variant information Variant position: help 63
Type of variant: help LB/B
Residue change: help From Alanine (A) to Aspartate (D) at position 63 (A63D, p.Ala63Asp).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and acidic (D)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 63
Protein sequence length: help 229
Location on the sequence: help WDAAIVLSKYLETPEFSGDG A HALSRRSVLELGSGTGAVGL
Residue conservation: help 
Human                         WDAAIVLSKYLETPEFSGDGAHALSRRSVLELGSGTGAVGL

Mouse                         WDAAIVLSKYLETPGFSGDGAHALSRRSVLELGSGTGAVGL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 229 Protein N-lysine methyltransferase METTL21D
Binding site 43 – 43
Alternative sequence 1 – 89 MADTLESSLEDPLRSFVRVLEKRDGTVLRLQQYSSGGVGCVVWDAAIVLSKYLETPEFSGDGAHALSRRSVLELGSGTGAVGLMAATLG -> MWGRLLQAFPPVPTPQSTLFYR. In isoform 2.
Mutagenesis 73 – 73 E -> Q. Loss of methyltransferase activity.
Beta strand 61 – 63



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.