Variant position: 181 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 509 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LREQEIVASSPSLSG--LKLGF ES----------IYKIPFADALDLFRGRKVY
Mouse LREQDIMASSPSLSG--IKLES ES----------VYKVPFA
Rat LREQDIMASSPSLSG--VRWES ES----------VYKVPFA
Caenorhabditis elegans AMIEDLEAACQ-FNL--FEAPN KT----------FYKVDFI
Drosophila EVKDGLYESTVGQSV--AKIEL LD----------FYKVPFT
Slime mold QYQDDLGYLVKKANLNLNEVNN TH----------FYKLPFQ
Baker's yeast ELSHQLYQTVSASLQFQLNLNE EHQRKQYFQQEKFIKLPFE
Fission yeast VFYEKLQASSQ------RNIEN ES----------FFKVPFF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 509 DNA primase large subunit
159 – 509 Missing. In isoform 2.
179 – 181
No reference for the current variant in UniProtKB/Swiss-Prot.
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