Variant position: 465 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 509 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NQFFCESQRILNGGKDIKKE PIQPETPQPKPSVQKTKDASS
Mouse NQFFFESQRILTGGKDIKKE ISQPETPQHKPSTQKTRDAAS
Rat NQFFFESQRILTGGKDIKKE ASHPETPQHKPSTQKTKDATS
Caenorhabditis elegans NQFYEESQKIVAERIAAKQE SQEAPAPKIEKMDTE------
Drosophila NNYFEES-QIAMGNRQKRAN GSAPPKARIRPDIKGHGDRSM
Slime mold NQFYDQSMEYYKTLEEKKSA KQSNNKENENQSIDEK-----
Baker's yeast NLYFERSRQLQKKQQKLEKE KLFNNGNH-------------
Fission yeast LQYFQLSLES---------- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 509 DNA primase large subunit
266 – 509 Interacts with PRIM1
470 – 470 Phosphothreonine
159 – 509 Missing. In isoform 2.
Large-scale proteomics analysis of the human kinome.
Oppermann F.S.; Gnad F.; Olsen J.V.; Hornberger R.; Greff Z.; Keri G.; Mann M.; Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009)
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-465; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.