Variant position: 2692 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2718 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FTKPSGQQTLSPDRQVPRPT ALPRRQPTVHFSDVSSDDDED
Mouse ----SAPPSLPTDRAAPRP- PVPHRQPIVHFSDVSSDDDED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2718 Zinc finger protein 40
2682 – 2682 Phosphoserine
A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.
Fan C.M.; Maniatis T.;
Genes Dev. 4:29-42(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS SER-1074; ASN-1170; ARG-1915 AND GLY-2692;
A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.
Baldwin A.S. Jr.; LeClair K.P.; Singh H.; Sharp P.A.;
Mol. Cell. Biol. 10:1406-1414(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 817-2718 (ISOFORM 1); VARIANTS ALA-873; ILE-1609 AND GLY-2692;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.