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UniProtKB/Swiss-Prot Q9Y6U3: Variant p.Ala443Pro

Scinderin
Gene: SCIN
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Variant information Variant position: help 443
Type of variant: help LB/B
Residue change: help From Alanine (A) to Proline (P) at position 443 (A443P, p.Ala443Pro).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 443
Protein sequence length: help 715
Location on the sequence: help DCYIILYTYPRGQIIYTWQG A NATRDELTTSAFLTVQLDRS
Residue conservation: help 
Human                         DCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRS

Mouse                         DCYIILYTYPRGQIIYTWQGANATRDELTMSAFLTVQLDRS

Bovine                        DCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRS

Chicken                       DCYIILYTYPKGQIIYTWQGACATKDELTASAFLTVQLDRS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 715 Scinderin
Repeat 398 – 451 Gelsolin-like 4
Region 364 – 715 Ca(2+)-dependent actin binding
Mutagenesis 455 – 455 F -> D. Loss of actin-binding.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.