Sequence information
Variant position: 594 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 779 The length of the canonical sequence.
Location on the sequence:
ATDTLDRTLGDKRHLVTVEV
E ARPIETSSVMPVIEFEYAES
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ATDTLDRTLGDKRHLVTVEVE ARPIETSSVMPVIEFEYAES
Mouse ATDTLDRVLGDKRHLVSAELE VRPAEEPCAVAKIE--YADC
Rat ATDTLDRVLGDKRHFARAELE VRPAEEPCGVATIE--YADS
Bovine ATDTLDRTLGDKRHLVTVELE AKPVETSSLLPVIE--YAAS
Zebrafish AKDLLDRILGEKRHVVSVELT VHPLKENSS-ASCDITFEED
Drosophila TTLSVEKEIAGSKQSVSITLE V--VKNQAELFSLD-KSPDN
Baker's yeast SETNIETYESDDGYRFSLSL- ---LPNSDALPNCL-AYPLG
Fission yeast NSVTLST---ENKENLIINVY LIPISDEGDETLKKYFSEGE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 779
Ribosome-releasing factor 2, mitochondrial
Alternative sequence
514 – 779
Missing. In isoform 5.
Alternative sequence
532 – 709
Missing. In isoform 4.
Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3); VARIANTS HIS-425; GLY-594 AND GLY-735;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.