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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P59536: Variant p.Pro127Leu

Taste receptor type 2 member 41
Gene: TAS2R41
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Variant information Variant position: help 127
Type of variant: help LB/B
Residue change: help From Proline (P) to Leucine (L) at position 127 (P127L, p.Pro127Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 127
Protein sequence length: help 307
Location on the sequence: help FCVKIANITHSTFLWLKWRF P GWVPWLLLGSVLISFIITLL
Residue conservation: help 
Human                         FCVKIANITHSTFLWLKWRFPGWVPWLLLGSVLISFIITLL

Gorilla                       FCVKIANITHPTFLWLKWRFPGWVPWLLLGSVLISFIITLL

Chimpanzee                    FCVKIANITHPTFLWLKWRFPGWVPWLLLGSVLISFIITLL

Mouse                         FCIKIANFSHPAFLWLKWRFPALVPWFLLGSILVSVIVTLL

Rat                           FCIKIANFSHPAFLWLKWRFPALVPWLLLGSILVSFIVTLM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 307 Taste receptor type 2 member 41
Topological domain 110 – 129 Cytoplasmic



Literature citations
The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.
Bufe B.; Hofmann T.; Krautwurst D.; Raguse J.-D.; Meyerhof W.;
Nat. Genet. 32:397-401(2002)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-127; Evolution of bitter taste receptors in humans and apes.
Fischer A.; Gilad Y.; Man O.; Paeaebo S.;
Mol. Biol. Evol. 22:432-436(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-127;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.