Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 161 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EEEEGKE----KKTFPIS---GARGGA RGTRYRYVSQAQPRGKPRQDT
Mouse EEDDNQTHLQIKRTFSGA---AGGNGA GSTRYRYQSQAQHK
Bovine QEEEDTE----KRTFPGSVGGGGGGGA GSTRYKYPSQAQFQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 118
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.
Lewis K.; Li C.; Perrin M.H.; Blount A.; Kunitake K.; Donaldson C.; Vaughan J.; Reyes T.M.; Gulyas J.; Fischer W.; Bilezikjian L.; Rivier J.; Sawchenko P.E.; Vale W.W.;
Proc. Natl. Acad. Sci. U.S.A. 98:7570-7575(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; SYNTHESIS OF UCN III; VARIANT GLY-91;
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.
Hsu S.Y.; Hsueh A.J.W.;
Nat. Med. 7:605-611(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLY-91;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT GLY-91;
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